Globally Responsive

CSS variables can be changed inside media queries. And by redefining a variable on :root in a media query, that variable will be globally responsive.
@media (max-width: 45em) {
:root {
--size-5: var(--size-4);

Javascript Interactivity

CSS variables can also be accessed and updated in JavaScript, which allows you to accomplish things that were previously very complicated, like dynamically applying style themes. By updating a few key variables based on user input, you can reskin an entire interface.
Update CSS variables in JS by using the setProperty method on the document root’s style property.`--color-primary`, `#4299e1`);
You can also alias variables to other variables, this is useful for using a consistent property throughout your codebase that can be dynamically updated without losing meaning.
function enableDarkMode() {`--color-background`, `var(--color-black)`);`--color-text`, `white`)
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